Sathyamangalam Tiger Reserve is about 75 kms from Coimbatore, about 225km from Bangalore, and about 65km from Udhagamandalam (Ooty) by road. Hasanur Division is 23 kms ahead from Sathyamangalam towards Chamrajnagar.
Parts of the Sanctuary is approached by Sathyamangalam-Dhimbum ghat road with 27 hair-pin bends.
The nearest railway stations to Sathyamangalam is Coimbatore, about 75km, Erode about 67km and Chamrajnagar about 40kms, which is the nearest town from Karnataka.
The nearest airports are Coimbatore (80 km) and Bangalore (225km). The nearest town for medical facility, petrol bunks is Sathyamangalam.